Archetypes of incumbents' strategic responses to digital innovation

Digital technologies (DTs) are significantly changing industrial and organisational activities, as well as the underlying processes and competencies. These impacts are particularly relevant when referring to firms’ business models, in particular on how incumbents have struggled to innovate their business model to react to the disruption triggered by DTs. These technologies have posed new challenges that seem to differ from those going along with previous technological shifts. We argue that such challenges depend on the incremental or radical nature of the technology at stake, as well as how far this is from the technological path of the incumbent, focal firm. By investigating how incumbents are adapting their business models in response to the disruption triggered by DTs, this paper proposes a conceptual matrix that draws on two dimensions: (i) the extent to which the impact of the digital technology is incremental or radical; and (ii) whether the industry of origin of the digital technology is the same or a different one from the focal firm. Through four illustrative case studies, we discuss different strategic approaches, highlighting how incumbents may mobilise different resources and assets following a more defensive or proactive posture in adapting their business model to the digital transformation

Off-label long acting injectable antipsychotics in real-world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study

Introduction Information on the off-label use of Long-Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on- vs off-label LAIs and predictors of off-label First- or Second-Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off- or on-label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with the choice of FGA vs SGA prescription in the off-label group. Results SGA LAIs were more commonly prescribed in everyday practice, without significant differences in their on- and off-label use. Approximately 1 in 4 patients received an off-label prescription. In the off-label group, the most frequent diagnoses were bipolar disorder (67.5%) or any personality disorder (23.7%). FGA vs SGA LAI choice was significantly associated with BPRS thought disorder (OR = 1.22, CI95% 1.04 to 1.43, p = 0.015) and hostility/suspiciousness (OR = 0.83, CI95% 0.71 to 0.97, p = 0.017) dimensions. The likelihood of receiving an SGA LAI grew steadily with the increase of the BPRS thought disturbance score. Conversely, a preference towards prescribing an FGA was observed with higher scores at the BPRS hostility/suspiciousness subscale. Conclusion Our study is the first to identify predictors of FGA vs SGA choice in patients treated with off-label LAI antipsychotics. Demographic characteristics, i.e. age, sex, and substance/alcohol use co-morbidities did not appear to influence the choice towards FGAs or SGAs. Despite a lack of evidence, clinicians tend to favour FGA over SGA LAIs in bipolar or personality disorder patients with relevant hostility. Further research is needed to evaluate treatment adherence and clinical effectiveness of these prescriptive patterns

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

An analysis of the design activity in the context of the agro-food industry in Italy between innovation and aesthetics

La tesi si prepone di analizzare il significato di design nel contesto dell’industria agro-alimentare in Italia, con particolare riferimento alle teorie dell’innovazione tramite servizi (Miles et al., 1995; Tether et al., 2001). Precedenti studi sulla professionalizzazione di una disciplina hanno supportato una prima fase di ricerca, durante la quale si è cercato di valutare se si sta sviluppando una disciplina del design agro-alimentare (Hodgson, 2002). Successivamente, la ricerca ha analizzato come le imprese del settore abbiano sviluppato ed integrato specifiche competenze mirate a fare del design uno strumento di crescita innovativa (Jennings e Wood, 1994, Meroni, 2000, Miele e Murdoch, 2002). La metodologia si basa su casi studio tratti da dati di fonte primaria e secondaria. Un primo risultato ha evidenziato l’importanza dell’innovazione di tipo organizzativo, in particolare il lavoro di progetto ed un rapporto frequente con il cliente. Lo studio enfatizza inoltre che le aziende agro-alimentari debbano considerare aspetti legati all’innovazione in concomitanza a quelli legati all’estetica. Nei casi in cui il prodotto non rappresenti l'unica interfaccia col cliente (es. settore vinicolo), la ricerca suggerisce che la funzione di servizio del design emerge come preminente.This thesis unveils the meaning of design in the context of the agro-food industry in Italy from a service innovation perspective (Miles et al., 1995; Tether et al., 2001). Different theoretical underpinnings have been called: previous studies on the professionalisation of a discipline have helped to assess the extent to which a discipline of agro-food design is emerging (Hodgson, 2002). Additional insight is provided by the analysis of firms and sectors that have integrated design-related expertise into their activities and, consequently, contributed to further our understanding on this matter (Jennings and Wood, 1994, Meroni, 2000, Miele and Murdoch, 2002). A qualitative approach has combined both primary- and secondary-source data. The study indicates that organisational innovations are crucial for the competitiveness of Italian design firms, project-based activity and close relationship with client firms in particular. Case studies on medium and large agro-food firms point to a blurring line between design and marketing. The study emphasises that both the innovation and aesthetic components must be considered. In cases where the product is not the only interface with the client (e.g. winemaking sector), the research suggests that the service trait of the design activity is becoming increasingly relevant

Persistence and learning effects in design innovation : evidence from panel data

This paper explores persistence and learning effects in the aesthetic and symbolic dimensions of design innovation. By combining insights from innovation economics and design studies, we discuss design innovation as the result of firm-specific cumulative learning. We then conceptualise design and product innovation as complementary processes whose interplay may lead to learning effects across different dimensions of knowledge creation. We provide quantitative evidence for these insights applying dynamic probit and bivariate probit models to a longitudinal dataset of manufacturing firms based in Spain for the period 2007-2016. Our findings confirm the presence of persistence effects in design innovation, offering novel evidence in support of the view whereby design is an iterative process shaped by the knowledge generated through firms’ previous engagement with design. In addition, the results contribute to our understanding of the role of design beyond its functional dimension, pointing to mutually reinforcing effects between aesthetic and symbolic design and product innovation

Research collaboration in Large Scale Research Infrastructures: Collaboration types and policy implications

Over the past decades, Large Scale Research Infrastructures (LSRIs) have come to play a central role in providing scientist-users access to highly specialised scientific instrumentation and experimental conditions. Collaborations between (permanent) instrument scientists and users are at the core of these organisations, yet knowledge about the nature of such collaborations and their development over time is surprisingly scarce. In particular, we know very little about the interrelation between the individual and organisational drivers of collaboration. Based on a qualitative study of scientists and their collaborations at Institut Laue-Langevin, a world-leading neutron source, we identify four typical collaboration patterns, which reflect particular configurations of (dis)similarity between instrument scientists and users in terms of perceived expertise gap and co-development focus. Our findings suggest that the co-existence of multiple collaboration types within the same organisation plays an important role in the long-term success of LSRIs. In addition, we contend that dissimilarity can generate productive collaboration to the same extent as partner similarity; not only at the organisational level – co-existence of different types of collaborations across the LSRI, favouring the co-existence of a broad range of instrumentation – but also at the individual level – where instrument scientists benefit in terms of more productive collaborations over time despite the cost of learning involved